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Ilva D Rupenthal Selected Research

tonabersat

2/2022Blocking connexin43 hemichannels prevents TGF-β2 upregulation and epithelial-mesenchymal transition in retinal pigment epithelial cells.
12/2020Tonabersat Inhibits Connexin43 Hemichannel Opening and Inflammasome Activation in an In Vitro Retinal Epithelial Cell Model of Diabetic Retinopathy.
1/2020Connexin Hemichannel Block Using Orally Delivered Tonabersat Improves Outcomes in Animal Models of Retinal Disease.
10/2019Targeting connexin hemichannels to control the inflammasome: the correlation between connexin43 and NLRP3 expression in chronic eye disease.
10/2017Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels.

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Ilva D Rupenthal Research Topics

Disease

18Inflammation (Inflammations)
12/2021 - 12/2011
13Diabetic Retinopathy (Retinopathy, Diabetic)
05/2022 - 03/2016
9Retinal Diseases
02/2022 - 03/2016
5Glaucoma
01/2021 - 09/2015
4Infections
01/2022 - 01/2016
4Macular Degeneration (Age-Related Maculopathy)
01/2020 - 03/2016
4Edema (Dropsy)
10/2017 - 12/2011
3Hyperglycemia
03/2021 - 11/2017
3Eye Diseases (Eye Disease)
03/2021 - 01/2018
3Ischemia
12/2017 - 10/2015
3Wounds and Injuries (Trauma)
10/2017 - 12/2011
2Type 2 Diabetes Mellitus (MODY)
05/2022 - 01/2019
2Keratitis
01/2022 - 01/2021
2Eye Infections
11/2019 - 09/2019
2Gliosis
01/2019 - 01/2018
2Geographic Atrophy
01/2019 - 01/2019
2Disease Progression
01/2018 - 11/2017
2Dry Eye Syndromes (Dry Eye Syndrome)
01/2017 - 01/2016
2Optic Nerve Diseases (Optic Neuropathy)
10/2015 - 07/2013
1Uveitis
12/2021
1Communicable Diseases (Infectious Diseases)
12/2021
1Herpes Zoster
03/2021
1Retinal Degeneration
02/2021
1Toxic Optic Neuropathy
02/2021
1Necrosis
01/2021
1Aneurysm (Aneurysms)
01/2020
1Animal Disease Models
10/2019
1Chronic Disease (Chronic Diseases)
10/2019
1Vascular Diseases (Vascular Disease)
01/2019
1Reperfusion Injury
01/2018
1Cataract (Cataracts)
01/2018
1Ganglion Cysts (Ganglion)
01/2018
1Spinal Cord Injuries (Spinal Cord Injury)
12/2017
1Neuroinflammatory Diseases
10/2017
1Migraine Disorders (Migraine)
10/2017
1Pain (Aches)
06/2017
1Hemorrhage
06/2017
1Retinal Detachment (Retinal Detachments)
06/2017
1Blepharitis
01/2017
1Carcinoma (Carcinomatosis)
07/2013
1Corneal Edema
03/2012
1Nervous System Trauma
02/2012
1Intractable Pain
02/2012
1Chronic Pain
02/2012

Drug/Important Bio-Agent (IBA)

19Connexin 43 (Connexin43)IBA
02/2022 - 12/2011
13Retinaldehyde (Retinal)IBA
02/2021 - 10/2015
11InflammasomesIBA
05/2022 - 01/2018
7Pharmaceutical PreparationsIBA
03/2021 - 01/2017
7ConnexinsIBA
02/2021 - 12/2011
5tonabersatIBA
02/2022 - 10/2017
4CytokinesIBA
01/2021 - 01/2018
4Peptides (Polypeptides)IBA
01/2018 - 07/2013
3Adenosine Triphosphate (ATP)IBA
02/2021 - 10/2017
3Ophthalmic Solutions (Eye Drops)IBA
02/2021 - 09/2015
2Biomarkers (Surrogate Marker)IBA
05/2022 - 01/2021
2Proteins (Proteins, Gene)FDA Link
05/2022 - 02/2021
2Retinal Pigments (Pigments, Visual)IBA
03/2021 - 12/2020
2Coloring Agents (Dyes)IBA
03/2021 - 01/2020
2Glucose (Dextrose)FDA LinkGeneric
01/2021 - 01/2021
2Local Anti-Infective Agents (Antiseptics)IBA
11/2019 - 01/2016
2SolutionsIBA
10/2019 - 01/2018
1NLR ProteinsIBA
05/2022
1AgarIBA
01/2022
1Adrenal Cortex Hormones (Corticosteroids)IBA
12/2021
1fluorescein isothiocyanate dextranIBA
03/2021
1isothiocyanic acidIBA
03/2021
1Fluorescein (Funduscein)FDA LinkGeneric
03/2021
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
03/2021
1NF-kappa B (NF-kB)IBA
03/2021
1Excipients (Suspending Agents)IBA
02/2021
1Hematoxylin (Haematoxylon)IBA
01/2021
1DNA (Deoxyribonucleic Acid)IBA
01/2021
1Interleukin-1beta (Interleukin 1 beta)IBA
01/2021
1Eosine Yellowish-(YS) (Eosin)IBA
01/2021
1Evans Blue (Blue, Evans)FDA Link
01/2020
1Povidone-Iodine (Betadine)FDA LinkGeneric
11/2019
1NucleotidesIBA
10/2019
1Leucine (L-Leucine)FDA Link
10/2019
1Azithromycin (Zithromax)FDA LinkGeneric
09/2019
1SuspensionsIBA
09/2019
1AlkanesIBA
09/2019
1Anti-Bacterial Agents (Antibiotics)IBA
09/2019
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2019
1Fluorescein-5-isothiocyanate (FITC)IBA
01/2018
1Therapeutic UsesIBA
12/2017
1Pyruvaldehyde (Methylglyoxal)IBA
01/2017
1Interleukin-6 (Interleukin 6)IBA
01/2017
1MicellesIBA
01/2017
1CyclodextrinsIBA
01/2017
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
01/2017
1CollagenIBA
03/2016
1Anti-Infective Agents (Microbicides)IBA
01/2016
1Cyclosporine (Ciclosporin)FDA LinkGeneric
01/2016
1AcidsIBA
10/2015
1Propidium (Propidium Iodide)IBA
07/2013

Therapy/Procedure

6Therapeutics
12/2021 - 01/2019
4Intravitreal Injections
01/2018 - 10/2015
1Microspheres (Microsphere)
01/2021
1Laser Therapy (Surgery, Laser)
03/2012
1Excimer Lasers
03/2012